

🛡️ Keep your baby’s skin happy and rash-free—because every diaper change deserves the best defense!
Desitin Daily Defense Baby Diaper Rash Cream features a clinically proven 13% zinc oxide formula that instantly forms a protective barrier to treat, soothe, and prevent diaper rash. Hypoallergenic and free from parabens, phthalates, fragrances, and dyes, it’s gentle enough for daily use on sensitive baby skin. Trusted by pediatricians and parents alike, this rich, creamy cream applies smoothly and wipes off easily, providing long-lasting protection and comfort for your little one.









| ASIN | B003DN1WJY |
| Best Sellers Rank | #4,158 in Health & Household ( See Top 100 in Health & Household ) #18 in Diaper Creams #515 in Sales & Deals |
| Customer Reviews | 4.8 4.8 out of 5 stars (17,662) |
| Date First Available | February 18, 2010 |
| Is Discontinued By Manufacturer | No |
| Item model number | 074300495163 |
| Manufacturer | Kenvue |
| Manufacturer recommended age | 36 months - 10 years |
| Product Dimensions | 3.62 x 3.62 x 3.82 inches; 1 Pounds |
E**Z
Great Diaper Rash Cream for Daily Use
Great Diaper Rash Cream This cream works really well for my baby. It helps prevent and soothe diaper rash quickly, and it’s gentle on sensitive skin. The texture is smooth and easy to apply, and a little goes a long way. I’ve noticed great results even with daily use. Definitely a must-have for babies.
J**E
Reliable Diaper Rash Cream for Prevention and Treatment
Desitin Daily Defense Baby Diaper Rash Cream has been excellent for both preventing and treating diaper rashes. The 13% zinc oxide formula creates a strong, protective barrier on my baby’s skin, helping to soothe irritation and keep new rashes from forming. It spreads easily, absorbs well, and provides long-lasting protection, even during long naps or overnight diaper changes. I find it very convenient to have a consistent supply, so I subscribed and now receive two tubes every four months — which ensures we never run out when we need it most. Overall, this is a dependable, high-quality diaper cream that keeps my baby comfortable and rash-free. Highly recommended for everyday use as well as for flare-ups.
C**Y
An absolute must-have — works fast and prevents future rashes!
Desitin Daily Defense has become one of my must-have baby essentials. It truly does what it promises — it treats and prevents diaper rash better than anything else I’ve tried. The formula with 13% zinc oxide creates a great protective barrier, and I love that it’s gentle enough for everyday use. What I appreciate most is how quickly it works. If my baby ever starts getting a little redness or irritation, I put this on and by the very next diaper change it’s noticeably better. By the end of the day, the rash is usually completely gone. The texture is thick enough to stay in place but still spreads easily, which makes diaper changes quicker and less messy. It also doesn’t have a strong smell, and it wipes off cleanly without irritating my baby’s skin. I feel comfortable using it daily to protect against moisture, especially overnight or on long outings. Overall, Desitin Daily Defense is reliable, effective, and truly lives up to its reputation. Every parent should have a tube of this in their diaper bag and at home — it simply works.
J**A
100% recommended excellent product
Excellent baby cream. It protects the skin from the very first use and helps prevent diaper rash. The texture is smooth and easy to apply. Highly recommended for daily baby care! 👶💙
J**T
Best diaper cream!
Only cream that works for us.
L**S
Long-lasting and reliable for everyday use
I have been using this cream for over six years. I first started using it with my daughter, and now I also use it with my baby. What I like most is how long it lasts — one container usually lasts about six to seven months with regular use. The texture is thick but easy to apply, and you don’t need a lot of product each time. It doesn’t have a strong scent and doesn’t feel sticky. It’s practical for everyday care and something I always keep at home. For me, it has been a reliable option over the years, which is why I continue to repurchase it. As a mom, it gives me peace of mind to keep using something I already trust.
P**.
My favorite diaper cream
Great product, good value for the money, and it works very well. My only complaint is that the container is very deep, and it's hard to get the cream out as you work your way down. It would be better if it were a little wider and less deep. Either way, great product and would recommend to a friend and will buy again.
S**Y
Perfect! And great value
Tried a lot and this works like a charm for my baby. Apply it as a defense and you’ll never see a rash, if you did, apply that too. The maximum strength one didn’t work for him. Every baby is different tho.
K**D
This is good 👍
W**O
excelente a melhor! faz muitos anos que uso a Desitin
A**I
ممتاز جدا للاطفال لكن السعر مرتفع نسبيا عن أي هيرب
M**M
المنتج وصلني مفتوحة العلبة والكريم طالع برا وملصق بتيب !! جدا غير مرضي
D**.
It is the best, its the only thing i use for my baby and will definitely buy it again.
Trustpilot
1 month ago
2 months ago