There are many types of liver injury, but only one is normally associated with the use of oral androgens -- cholestasis. This condition is defined as a failure of normal bile to reach the duodenum, which may be due to a number of different pathological states between the hepatocyte and the ampulla of Vater. When one takes oral androgens (typically methylated at C17a) the physical structure of the hepatocyte is altered -- microfilaments and canaliculi become less contractile. Disruptions in the canalicular bile salt export pump may also occur. This leads to impaired bile flow and the retention of highly cytotoxic hydrophobic bile salts. At low concentrations, these retained bile salts cause apoptosis; at higher concentrations, necrosis and severe liver damage. This is where AEGIS comes into the picture. AEGIS was designed with users of oral androgens in mind, and brings together the best anti-cholestatic ingredients available. Aegis is highly-potent, highly-specific liver protection for people taking hepatotoxic oral androgens. Superior protection cannot be bought, nor should it be needed. Reduce steroid and drug-related toxicity. Support optimal liver health and bile flow. High-potency blend of two cytoprotective ingredients. Ideal for people exposed to environmental toxins or hepatotoxic oral androgens. Ingredients: Tauroursodeoxycholic acid: Can prevent apoptosis during cholestasis. Toxic bile acids produce apoptosis Via fas- and TRAIL- death receptor mediated pathways. Both are, to some degree, dependent on the translocation of the 'bax' pro-apoptoic molecule from the cytosol of hepatocytes to the cell mitochondria. TUDCA prevents bax translocation, strongly stabilizes mitochondrial membranes, and activates the MAPK pro-survival pathway in hepatocytes. (1) These effects protect hepatocytes from bax-related apoptosis. Is a hydrophilic bile acid, and its presence markedly shifts the bile pool towards hydrophilicity, which, to some extent, detoxifies it. W
B**E
Yes this REALLY does work!
Yep. As advertised. This brought my elevated liver values right down. This stuff really does work. Yes, I cleaned up my diet and exercise routine. But the speed at which my liver values improved I attribute to this supplement. I used to have NAFLD. Now I do not. One bottle did the trick. But I still take it to ensure my liver values stay good.
J**O
Best liver protection out there
Great product. Great ingredients just wish it could all be packed into less pills but either way great product, will definitely buy again.
M**
Five Stars
Good product
D**H
Five Stars
Most powerful liver protector
B**P
Best Liver Protection
This is the best liver protection you can buy but it is available from another seller for $42.94 under A: Liver Protection. No other product comes close to this one.
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3 days ago
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