Angiopoeitin-1 (Ang-1) and Angiopoietin-2 (Ang-2) have importance in the development of the endothelium by regulating tyrosine phosphorylation of the membrane receptor Tie-2/Tek. Ang-1 binding to Tie-2/Tek causes phosphorylation of the receptor. Ang-2 competes for this binding, and thus blocks receptor phosphorylation. Ang-1 has a potential fibrinogen-like domain at the carboxyl terminus and coiled-coil regions in the amino terminus. Ang-1 is prominently expressed in the myocardium of atrium and ventricle, mesenchymal and smooth muscle cells surrounding most blood vessels, and lung. In the adult, Ang-1 is also expressed in the heart and liver. Angiopoietin-1 antibody can be used in ELISA starting at 1 ?g/mL, Western Blot starting at 1 ?g/mL, and immunohistochemistry starting at 10 ?g/mL. Sterile Filtration 0.02 M potassium phosphate, 0.15 M NaCl, pH 7.2, 0.01% sodium azide. Aliquot and store at -20ﾰCor below. Avoid multiple freeze-thaw cycles. Type: Antigen: ANGPT1Clonality: PolyclonalClone: Conjugation: UnconjugatedEpitope: Host: RabbitIsotype: Reactivity: Human, Mouse
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